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Chemical Reaction Technologies

Customized Processes for Pharmaceutical Chemicals

Reaction Technologies

SGRL has its own manufacturing, research and quality control facilities at one place. It allows us to utilize the reaction technologies for customized reactions for complicated processes and advanced pharmaceuticals. We can handle any chemical reactions and we assure our expertise in chlorination, reduction, oxidation, bromination, esterification and Grignard reactions.

Chlorination + -

Whether it is for the production of our largest single product, 2-Chloro- N,N-diethylethylamine hydrochloride, or for the manufacture of chlorination reagents and downstream fine chemicals or for custom synthesis, chlorination reactions are of central significance to SGR’s products.

For environmental protection, we always convey chlorination reagents in closed systems. Gaseous secondary products or by-products from the chlorination processes are recycled and or converted into suitable secondary products which can be sold in to market.

CUSTOMER BENEFITS:

  • Backward integration into reagents and chlorinated intermediates
  • Sustainable production processes
  • Efficient chlorination in batch processes
  • Environmentally friendly recycling of sidestreams.

CHLORINATION using THIONYL CHLORIDE is at core expertise for SGRL.

Molecules bearing functional groups, such as alcohols, carboxylic acids or sulfonic acids, are chlorinated using thionyl chloride as chlorination reagent, the corresponding alkyl and aryl chlorides, carboxylic acid chlorides and sulfonyl chlorides being obtained. HCl and SO2 are formed as off-gases during chlorination reactions with thionyl chloride.

SGRL can offer custom chlorination reactions within its integrated manufacturing system, in which off-gases are separated, purified and returned to the system as feedstocks. This permits sustainable production from pilot quantities to large commercial volumes using both batch and continuous processes.

This increases yield and purity and reduces the proportion of unwanted secondary products.

Grignard Reactions + -

The Grignard reaction is a method for linking carbon-carbon single bonds. The corresponding alcohols are produced by reacting mainly nucleophilic alkyl- or arylmagnesium halides with electrophilic compounds such as aldehydes, ketones or esters. Grignard reagents are also important in the production of boron derivatives for subsequent use in the Suzuki coupling reaction.
CUSTOMER BENEFITS:

  • Extensive experience of Grignard reactions
  • Safe and robust processes for handling hazardous reagents and intermediates

Grignard_reactions_Intermediates

Hydrogenation / Reduction + -

Reducing aromatic nitro compounds with hydrogen in the presence of catalysts yields the corresponding aromatic amines, while aryl halides are reduced to aromatics. SGRL routinely carries out such reduction processes in the presence of palladium or platinum catalysts on its  site, making use of high grade infrastructure which ensures safe material handling.

CUSTOMER BENEFITS:

  • Safe handling of pyrophoric catalysts
  • Safe and robust production processes

Reduction_Hydrogenation_Intermediates

Oxidation + -

In addition to chloroxidation, SGRL also carries out oxidation reactions with hydrogen peroxide. Using hydrogen peroxide for oxidising aliphatic thiols and thioethers to yield sulfonyl chlorides, sulfoxides and sulfones is an alternative to chloroxidation. Oxidation reactions may also be carried out on a catalyst using air.

CUSTOMER BENEFITS:

  • Extensive experience of handling hydrogen peroxide reactions
  • Safe and robust production processes

Oxidation_Intermediates

Bromination + -

SGRL has the infrastructure and know-how to carry out bromination on a large industrial scale. SGRL operates dedicated assets for bromination reactions, including storage facilities, pipelines and appropriate safety measures.

CUSTOMER BENEFITS:

  • Long-standing experience in bromination reactions
  • Infrastructure for large scale commercial bromination reactions

Bromination_Reaction_Pharmaceuticals

Esterification + -

When a carboxylic acid is treated with an alcohol and an acid catalyst, an ester is formed along with water. This reaction is called the Esterification or Fischer esterification.The alcohol is generally used as solvent so is present in large excess. Many different acids can be used, although H2SO4 (sulfuric acid) and TsOH (tosic acid) are also often used.

Esterification_Pharmaceuticals